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Age Regression
Changes in aging is not from loss of function (that something is missing), but an increase of pathogenic damage (diseases of aging emerging in old organisms), requiring a cell-mediated response.

Theorists, Historians

  • Max Spiers | proposed many abstract theories, explained the increasing failure of governments and religion to provide a stable and unifying framework for the organisation of material life, the rise in control of city-states, national monarchies, conditioning of the masses, the magic spell within languages, and the breakup of the feudal structures.
  • Elizabeth Bathory wiki | audio clip | 21.00 blood rejuvenating, 22.10 lambs placenta, 22.20 blood as face cream
  • COVID conspiracy Dr. Adeel Khan, Circulating Spike Protein Detected in Post–COVID-19 Vaccinated are not allowed to donate placenta / umbilical cord for stem cells.
  • The Renaissance brought about a series of social, political, and intellectual transformations culminating in Humanism. Researching "adaptive regeneration capability" can exert mastery over nature by diagnosing aging symptoms of gerontology, offering dignity of man by health. The effect of humanism, break free from the mental strictures imposed by religious orthodoxy, to inspire free inquiry, criticism, animal studies : breaking down into a range of essential damage repair processes, inspire a new confidence in the possibilities of human thought and creations.

  • Video : (Max Spiers | planarian regeneration enhanced DNA repair, compare to human germ line by in vitro tissue culture based approach (cell biopsy assay) to gauge for longevity, knock down some of these enzymes, increase somatic mutation rates and show we have accelarated aging to identify the pathways how this influences epigenetic status, , GDF11's molecular structure is conserved across all vertebrate species, Core DNA contains holographic storage of previous ages)
    Plasmapheresis :

    Image : Age Reversal Interventions: lifespan-extending effect in elder people :

    Age Regression / Cell Reprogramming / Damage Repair / Rejuvenation Therapeutics i.e. IPS,MSC, Plasmapheresis

    Age Delaying / Age Slowing / Preventative (Geroprotective Therapy) i.e. Supplements, HBOT

    "Two thirds" of the human body is water contained intracellularly (liver, brain, muscles). Next being water in blood plasma. Lastly is water everywhere else (interstitium : connective tissue).

    Plasma is the liquid portion of blood. About 55% of the blood is plasma, with the remaining 45% are red blood cells, white blood cells and platelets that are suspended in the plasma. 92% of blood plasma is water, while 8% consists of dissolved substances, mostly proteins. Blood plasma also contains electrolytes, vitamins and nutrients such as glucose and amino acids.

    Old blood plasma removal/dilution improved bodily function by resetting signalling pathways to a core gene expression, reduce "inflammatory response, biological noise and DNA damage" whilst boosting stem cell proliferation

  • Susan Main, Nurse Clinician | What is Plasmapheresis
  • A dielectric study | on human blood and plasma
  • Louis Hawthorne | Apheresis treating aging, leukemia and myasthenia gravis
  • Louis Hawthorne | Apheresis treating aging removing aging factors
  • Young plasma has special proteins that rejuvenate tissues | Reverse Aging
  • Albumin conspiracy Donating Plasma just as effective as TPE

  • Lower Video : Heterochronic parabiosis researched pathogenic / parasitical old blood plasma (OP) to pristine young blood plasma (YP).

    Primarily the joining of live mice involved the sharing of organs, which improved the old mouse to the detriment of the young mouse.

    Secondarily centrifuging (OP) seperates "blood plasma" that contain suppressive "pro-aging" factors. Transfusion of (OP) to young mice created aging symptoms.

    Oppositely centrifuging (YP) seperates "blood plasma" that contain rejuvenating, youthful factors, which rejuvinate by proxy when transfused to old mice.

    Finally only centrifuging (OP) seperates "blood plasma" that contain suppressive "pro-aging" factors. An equal volume saline replacement of the (OP) reproduced the rejuvenating effect without any need for (YP). This resulted in the clinical study "Old plasma dilution reduces human biological age"
    Age Regression :

    Upper Video : (Dr Aubrey de Grey regenerative small molecules, stem cells therapy currently available, Prof Arnold Caplan extending healthspan, preventative therapy before sickness, future damage repair will rejuvenate,Dr Michael D. West exorbitant charges, Dr. Charles Brenner refers to Vadim N. Gladyshev : dividing cells dilute atrophy, future IPS cells targeting Fibroblasts, Core DNA contains holographic storage of previous ages)

    Approach of partial reprogramming using nanoparticles in mRNA
    Stem Cells, Liposomal, Lysosome, Spatial Transcriptomics, Oligonucleotide

  • Asymmetric cell division | produces two daughter cells with different cellular fates. This is in contrast to symmetric cell divisions which give rise to daughter cells of equivalent fates
  • Dedifferentiation | is a transient (short-lived) process by which cells become less specialised and return to an earlier cell state within the same lineage
  • CRISPR | is the exploitation of a bacterial mechanism, that allows bacteriophages to defend themslves against viruses. CRISPR allows us to change the sequence of our genome in a particular cell (gene editing)
  • Dr Duncan Ross | For rejuvenation: Middle age to start using Exosomes is when largely healthy . elderly have risk being immunocompromised.
  • Dr. Neil Riordan | MSC's bud off microvesicles which are large enough to contain mitochondria | Anti cancer effects of MSC's, exponential increase in cronic disease in aging.
  • Dr Duncan Ross | Exosomes How They Contribute To Our Health.
  • Dr Aubrey de Grey | MSC Secretome broadly improve cell performance (well being), not focused damage repair rejuvenation
  • Dr Aubrey de Grey | repairing 7 types of damage

  • Image : reactivation of endocrine system : (hypothalamus, pituitary gland) increasing libido / anger

  • Prof Arnold Caplan | Tissue Engineering MSC's dependant on FBS in media, Embryonic Stem Cells and/or IPSC as Conductive Agent (starting material / catalyst) to stimulate far greater divisions (inductive capacity) to differentiate and expand in vitro cell culture for Tissue Engineering. Collagenases are, enzymes that break down the native collagen that holds animal tissues together.
  • Dr Michael D. West | Regenerative Medicine and Aging : Embryonic Progenitor Secretome influence physiology from the basis of cell function at the ionic and molecular level to the integrated behaviour of the whole body and the influence of the external environment.


  • Rotating Animation : 4 types of glial cells are: (1) microglia, (2) astrocytes, (3) oligodendrocytes, and (4) their progenitors NG2-glia. Dongsheng Cai's research showed inflammation, created from Glial cells, are a driving factor in the hypothalamus which causes aging through out the whole body.

  • Dr Ed Park | Mitigating aging with exosomes : Epiphany combining supplements with exosomes increasing longevity whilst countries spend trillions inciting wars and unrest.
  • Yuri Deigin | Epigenetic Rejuvenation by In Vivo Partial Reprogramming: Past, Present, and Future.
  • Bill Faloon | Stem Cell Regeneration, Young Plasma Infusion, GDF11 Restoration, Senolytics and Senomorphics, Therapeutic Extracellular Vesicles, Mesenchymal Stem Cells, Therapeutic Plasma Exchange, Self-Funded Clinical Research, Clinical Trial Development
  • Dr Michael D. West | induced tissue regeneration, primordial germ cells. Thomas Kirkwood has a theory called "Disposable Soma", that in nature there is not enough energy for repair and reproduction. An animal devotes its energy to reproduction and leaves repair to the germline cells. During fertilisation the early embryo retains the same epigenetic age signature of its mother until it reaches the "Gastrula Stage" where the embryo's own genes start to take the place of the maternally implanted genes that have been operating it. Gastrulation occurs during week 3 of human development, which the clock resets to zero. The process of gastrulation generates the three primary germ layers which primes the system for organogenesis and is one of the most critical steps of development
    • Ectoderm (ectoderm)
    • Endoderm (digestive tube and the respiratory tube)
    • Mesoderm (e.g. mesenchymal originates from smooth muscle cells)
    The gastrula is an embryo at the stage following the blastula, when it is a hollow cup-shaped structure having three layers of cells. It is not the blastula cells that maintain their perfect fidelity. The return to perfect fidelity is a natural aspect of organisms, it is possible to reset the clock of cell aging by cloning technology (Somatic cell transfer, transplanting nuclei from adult cells into oocytes or blastocysts and allowing them to grow and differentiate, producing pluripotent cells) and also by IPS cells. Alternatively approach near pluripotency targetting factors during the "embryonic fetal transition" (~ week 8 from regenerative to fibrotic). Companies in partial reprogramming : YouthBio Therapeutics, Altos Labs, Retro Biosciences, NewLimit, Turn Biotechnologies, Iduna Therapeutics, Shift Bioscience, AgeX Therapeutics, Calico, YouthBio Therapeutics, Gameto, BlueRock Therapeutics (for Embryonic Stem Cell-Derived Midbrain Dopamine Neuron Cell Therapy (MSK-DA01) For Advanced Parkinson's Disease)
  • Stem Cell Recipients

    Right Video : (Dan Bilzerian's Response to Dr. Neil Riordan's "Magic Juice" (aka Mesenchymal Stem Cell Conditioned Medium))

  • Consistently reports of Mesenchymal stem cells only offer a transient repair to wound healing


  • Left Video : (Dr Ed Park : Secretions of young MSC's Extracellular vesicles (EVs) dissipate (to separate and go in different directions) by diffusion (diffused or dispersed)

    Paracrine Signaling : is a form of cell signaling, a type of cellular communication in which a cell produces a signal to induce changes in nearby cells, altering the behaviour of those cells

    Endocytosis is a cellular process in which substances are brought into the cell. The material to be internalized is surrounded by an area of cell membrane, which then buds off inside the cell to form a vesicle containing the ingested material
    )


    Age Delaying :

    Supplements, Clips, Articles

    Senolytics

    Upper Image : Strawberries contain 160 μg/g of Fisetin

  • Research show Strawberries contain Fisetin protein, a powerful Senolytic. Fisetin, a dietary antioxidant for health promotion and gives neuroprotection. Fisetin possesses antiproliferative properties against several cancers: Lung cancer, colon cancer, prostate cancer, pancreatic cancer, melanoma. Research shows that Fisetin counteracts the stem cells therapy so is not taken in conjunction. |
















  • Deregulated Nutrient Sensing

  • Strategies Healthy Longevity (Prof Brian Kennedy) | Biological Age fluctuates with Healthy Lifestyle, Ca α‐KG, not contained in diets , negative effects of getting old then watching Television , use Ca α‐KG at middle age when at risk of disease
  • Ca α‐KG Increases

  • Ca α‐KG supplement increases both lifespan and healthspan
  • DNA methylation age decreased by 8.31 years (10% life extension)
  • Ca α‐KG increases healthspan of older aged by 40%(activities of daily living)
  • Revitalising cellular energy to restore vitality (metabolic function)
  • Helping to identify and fight pathogens
  • Improved Mental Acuity
  • Improves Muscle Repair (Protein synthesis)
  • Increases Adult stem cell function
  • Improves Metabolic flexibility (ability to adapt to conditional changes in metabolic demand) e.g Significantly increasing circulating levels of insulin
  • Tricarboxylic acid (TCA) cycle involved in central metabolism
  • Tricarboxylic acid (TCA) cycle involved in Amino Acid catabolic processes
  • Effects Oxidative Stress / Enhanced Respiration (the capacity for the organism to adapt fuel oxidation to fuel availability)
  • Enhances Cellular Respiration
  • Activates HIF-1α, which is a low oxygen response that has been shown to affect aging
  • Red Blood Cells readily take up AKG driving Glutathione production (better exercise endurance)
  • Improved hair condition, colour and hair growth
  • Supporting the immune system
  • Altered Microbiome function
  • Ca α‐KG Decreases

  • Reduced inflammation
  • Ageing Research on Ca α‐KG reduces Epigenetic Age in Humans
  • Reducing 30+ signs of age-related frailty (morbidity), and fertility decline
  • Reducing protein breakdown, harmful oxygen molecules within cells and prevents damage to tissues
  • Reduced mTOR signaling and attenuates Wnt signaling, suppresses ATP synthase
  • Detoxifies Hydrogen Peroxide (H202) and Ammonia (NG4+) into Glutamate, which becomes Urine


  • Extending Healthspan (Prof Brian Kennedy) | Ca α‐KG, human clinical trials & aging biomarkers, definition of aging , adult stem cell reprogramming
  • Ca α‐KG (Prof Brian Kennedy) | preventive medicine in an aging society (beyond healthcare to health)
  • Ca α‐KG longevity | reduced dermatitis
  • Ca α‐KG | interview with Tom Weldon effects on epigenetic age & health |
  • 17-α estradiol | male lifespan extension of median increase in survival of 19%
  • Seven Roots of Aging

  • 1. Waste Within Cells : Transgenic microbial hydrolases

    For metabolic reactions to synthesise the proteins or hormones required for life sustenance, our cells produce and accrue waste products inside them. However, as people get older, their “cell waste” disposal capabilities deteriorate, triggering molecular debris and protein accumulation in cells. The resulting debris and protein aggregations propagate tissue breakdown and organ dysfunction, leading to age-related diseases like metabolic disorders, cardiovascular ailments, and eventual death.

  • 2. Waste Between Cells : Phagocytosis by immune system

    Proteins and other cellular debris can accumulate outside and between cells begetting their pile up. Resulting debris and protein conglomerations impede cellular connections and their communication with other surrounding cells, triggering cell death, tissue and organ dysfunction, and eventually diseases that provoke death.

  • 3 and 4. Stem Cell Loss and Higher Levels of Senescent Cells : Stem Cells and Suicide genes, immune stimulation

    As we get older, aged, non-proliferating cells called senescent cells that release a milieu of inflammatory substances build up in our bodies and cause age-related inflammation (inflammaging). Aubrey de Grey proposes that during our lifetime, the ratio of healthy stem cells to senescent cells diminishes, resulting in an imbalance that constitutes a major origin of aging.

  • 5 and 6. Genetic Mutations : Telomerase/ALT gene deletion plus periodic stem cell reseeding and Allotopic expression of 13 proteins

    Two types of mutations that can impart aging, disease, and ultimately, death include those to DNA that codes for proteins used throughout the body (nuclear mutations) and others for the cell’s power-generating structure — the mitochondria. Nuclear mutations can cause diseases like cancer and diabetes, while mitochondrial mutations limit the cell’s capacity to produce energy and result in mitochondrial diseases that lead to death.

  • 7. Bonds and Interconnections Between Proteins : Age breaking molecules/enzymes

    As the final aging cause, de Grey proposes that bonds and links between cells that allow them to communicate and form cohesive tissues over-accumulate during aging. The multiplication of bonds connecting cells then causes a detrimental loss of tissue elasticity and can facilitate diseases like arteriosclerosis — the hardening of blood vessel walls.