Plasmapheresis
Old plasma separation removes Amyloid β (Aβ) plaque and Tau bound to Albumin
Therapeutic Plasma Exchange (TPE) :
Gemma Ortega Assessment, Dr. Juan Pablo Tartari Assessment, Patricia Gil de Sola from ACE Alzheimer Barcelona jptartari@fundacioace.org , pgil@fundacioace.org
Plasmapheresis technique can reverse aging, tested by Age Related Biomarkers And Epigenetics. Centrifugal force removing cell membranes, immune complexes (foreign molecules), antibodies, low-density lipoprotein (LDL cholesterol), microplastics, "synergetic" age related substances and toxins (improving cell communication), reduce progression of Dementia / Alzheimer’s disease, prevent age related disorders reducing cellular senescence and increase Angiogenesis .
Apheresis Diagram: The blood is passed through an apparatus that separates out one particular constituent and returns the remainder to the circulation.
research is directly linked to Alzheimers disease
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Chart "Relative rejuvenation" : shows the average of the selected proteins in each group is normalised by the old group. The net change between groups shows relative rejuvenation even at middle age. Middle age can be reset to lower aged proteins than that of the young control group. The age (40, 60, 70) indicates the lowest age reduction in each age group. Analysis of the relative biological noise age via TPE treatment demonstrated that it becomes reduced more sharply in individuals aged 60-70+ years, as compared to people who are 46-52 years old
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Chart TPE reduces biological age : shows biological age shifts after repeated TPE treatment. Compared to before TPE treatment, all patients show a decrease in biological age in the last round of TPE, demonstrating significant rejuvenation by TPE. |
endocytosis. Small molecules are more promising than proteins because small molecules are the main components of cells and have no major histocompatibility antigens. Glymphatic System. During sleep, cerebrospinal fluid squirts into the brain clearing Amyloid β (Aβ) plaque and Tau, reduces neuroinflammation which causes rejuvenation effects on the brain. The glymphatic system is a glial-dependent waste clearance pathway in the brain, in place of lymphatic vessels, dedicated to drain away soluble waste proteins and metabolic products. Microglia are resident cells of the brain that regulate brain development, maintenance of neuronal networks, and injury repair. Neurons are responsible for sending and receiving neurotransmitters-chemicals that carry information between brain cells. Neurons which do not divide but are physiologically dependant on Microglia which does divide and have turnover. Resetting signalling pathways to a core gene expression using Plasmapheresis will have an effect on Microglia. antagonistic pleiotropy hypothesis.The "feedback loop" generates cellular damage, even at middle age. Aging is malleable using Plasmapheresis for multiple organs: liver, muscle, brain, neuro-plasticity cognition, spinal cord health, kidney, bone, cartilage, etc. peripheral sink hypothesis. Amyloid β (Aβ) plaque, comprised mainly by Aβ peptides, is an important pathology of Alzheimer’s brains. Neurotoxic Aβ peptide is found in both the brain and the periphery. In the blood plasma there is some form of equilibrium for the Aβ. Aβ can be transported across the blood-brain barrier. By modulating the periphery Aβ levels, it is predicted that the brain Aβ levels will undergo concomitant changes, forming the basis of the “sink hypothesis” for lowering Aβ.
Image : Plasmapheresis no Human Serum Albumin (HSA) Replacement. No contaminated Human Serum Albumin (HSA) from donated human plasma. Within 3 days Albumin returns back to normal levels. Foods to support Albumin Levels (e.g. eggs). whilst remaining fully hydrated from loss of fluids.
Haemonetics PCS2 Used (£2,018 / €2,350)
Haemonetics : Ian Swann ISwann@haemonetics.com, Helmut Hanske hhanske@haemonetics.com, Luca De Rosa LDeRosa@haemonetics.com, Training Haemonetics bcdigital@haemonetics.com
The PCS2 offers self-loading pumps, auto-priming, comprehensive messaging, high quality optical sensors, minimal alerts, and an easy-to-read display. With multiple safety features, including redundant air detectors, a donor line pressure monitor, a fluid sensor, and an enclosed centrifuge. The PCS2 is small, lightweight, and easy to move. The PCS2 system also includes multiple protocols, and is intended for use as an automated cell separator system and blood component collector in conjunction with single use sterile disposable sets. Products that can be collected using the PCS2 system LN6002 automated cell separator include source plasma, plasma for reinfusion and plasma and leukocytes. The PCS2 can use a wide range of disposable harnesses which are all single needle : Regulation Stages : 
CEC 127555 from Yvonne, 10 South Colonnade, Canary Wharf, London E14 4PU. Tel: 020 3080 6000 MHRACustomerServices@mhra.gov.uk The National Institute for Health and Care Excellence contacted to find others clinics registered to provide plasmapheresis for plasma removal. NHS Blood and Transplant contacted Teresa Baines, Head of TAS / Deputy Chief Nurse Clinical Services. E-mail: teresa.baines@nhsbt.nhs.uk. TAS will offer plasmapheresis on a referral from a consultant, but cannot offer medical supervision from another nurse who has apheresis experience to oversee the process. NHS Blood and Transplant James Griffin explained rules E-mail: James.Griffin@nhsbt.nhs.uk.
A specialist to make an assessment of the patient and suitability for plasma exchange sending a NHS referral form, NHSBT would screen the referral and discuss with the consultant if required. If the consultant doesn’t work for an NHS organisation then a service-level agreement (SLA) is a contract between a service provider and its customers that documents what services the provider will furnish and defines the service standards the provider is obligated to meet. A service-level commitment (SLC) is a broader and more generalised form of an SLA. NHSBT would need to agree one off terms and conditions and invoicing arrangements as well as the clinical discussion. The AMBAR study was phase 3 but not good enough data to fund plasma exchange (PEX). Plasma exchange (PEX) involves a machine that removes patients' plasma and replaces it with fresh plasma. No safety concerns in this setting. As such if we have capacity we can do it but not clearly plasmapheresis would provide benefit and not sure if the patient will be fit enough. Would be better if there is a trial to be part of that. JPAC : Joint United Kingdom (UK) Blood Transfusion and Tissue Transplantation Services Professional Advisory Committee, Vivian Sproule, Donor Feedback Manager, Ref: KH/CAS-265629-P2H7R4. E-mail: customer.services@nhsbt.nhs.uk
Care Quality Commission contacted Jennie Mackle, NCSC Co-Ordinator, Inspection Support enquiries@cqc.org.uk for outpatient plasmapheresis treatment with reference ENQ1-16295005762. The Health and Social Care Act 2008 : Regulations 2014 are the regulated activities specified for the purposes of the Act. Regulated activities specified in Schedule 1 in England, require registration with CQC unless an exception or exemption applies under Section 8 "Supply of blood and blood derived products".
Decision tool to help determine whether medical practitioners are required to register with CQC for providers of an independent or private service" lists : CQC Submission tool by responseTraining Stages : 
Part 1 - Live Blood Sessions -  £227- NHS Phlebotomy Training Course. Maxis Healthcare UK Limited, 59 Greenford Avenue, London, W7 1LLPart 2 £250/- Live Blood Training Sessions with patients at the NHS with Azmat Sabir, Hammond Road Surgery, 95 Hammond Road, Southall, Middlesex, UB2 4EH. Certificate of Competence Phlebotomy + Essential practical experience with real patients. Online test, to receive "Certificate of Completion for the Precertification Test"Haemonetics Running steps Danish to English :  PCS2 SystemTest Express Logo close the centrifuge lid) open the centrifuge cover)
Daeksel lukket (Cover closed), L/S installeret (L/S installed), DPM installeret (DPM installed) install the disposable) do not spike washing bags (R) now install the Disposable) remove memory protection) - Toggle the write protect switch on the Processor Card (list card on the left side, at the bottom is the silver switch) 2-5 channel 1 mode error code - 32 press no for procedure state), CHANNEL 1 STATE ERROR, Safety system relay did not close during system start-up. Channel 1 state test.HaemoneticsRunning steps English :  replace memory protection) - now in English close the centrifuge cover) open the centrifuge cover) DO NOT SPIKE SOLUTION BAG(S) NOW PLEASE INSTALL DISPOSABLE) Haemonetics PCS2 - Operation manual Haemonetics PCS2 - Service manual Haemonetics PCS2 - Specifications Plasma Collection System comparison PCS2 (BK150292) vs newer PCS 300
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New (£62,000)
Used (£25,000)
Used (£12,000)
